rac-7-[(2E)-But-2-enoyl]-13-chloro-N-cyclohexyl-7,8-dihydro-5H-isochromeno[4,3-c]phenanthridine-8-carboxamide

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rac-7-[(2E)-But-2-eno­yl]-13-chloro-N-cyclo­hexyl-7,8-dihydro-5H-isochromeno[4,3-c]phenanthridine-8-carboxamide

In the title compound, C(31)H(29)ClN(2)O(3), the two heterocyclic rings, belonging to a system of five condensed rings, adopt conformations intermediate between twist-boat and sofa. The secondary amide group is involved in a weak intramolecular N-H⋯N hydrogen bond. In the crystal, molecules are linked by pairs of C-H⋯Cl hydrogen bonds to form inversion dimers. These dimers are linked via a C-H⋯...

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In the title compound, C(26)H(20)N(2)O(3), the two aromatic rings of the tricyclic unit are oriented at a dihedral angle of 54.53 (9)°. The crystal structure displays inter-molecular N-H⋯O hydrogen bonding.

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A convenient method for 14C-labeling of N-(7-chloro-1- methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[ e][1,4]diazepin-3-yl)thiophene-2-carboxamide as CCK-A antagonist

N-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)thiophene-2 carboxamide-[14C-carboxy] was prepared as part of a 6-step sequence from thiophene-2-carbonitrile -[cyano-14C] as a keysynthetic intermediate which has been synthesized from 2-iodothiophene and zinc [14C]-cyanide in thepresence of tetrakis (triphenylphosphine) palladium.

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In the title compound, C(19)H(14)Cl(2)F(3)N(5)O(2), which shows insecticidal activity, the dihedral angle between the pyrazole and pyridine rings is 68.15 (16)°. In the crystal structure, the mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds and an intra-molecular N-H⋯O inter-action also occurs. The F atoms of the -CF(3) group are disordered over two sets of sites in a 0.800 (8):0.200 (8)...

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N-(3-Bromo-1,4-dioxo-1,4-dihydro-2-naphth­yl)-2-chloro-N-(2-chloro­benzoyl)benzamide

The title compound, C(24)H(12)BrCl(2)NO(4), was synthesized from 2-amino-3-bromo-1,4-naphthoquinone and 2-chloro-benzoyl chloride. The crystal structure shows that each of the chloro-phenyl rings is inclined at about 60° to the naphthoquinone ring system. The two chloro-phenyl rings adopt a conformation that ensures that chlorine substituents are anti so as to reduce electronic repulsion. An ex...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online

سال: 2012

ISSN: 1600-5368

DOI: 10.1107/s1600536812005946